Injection 头孢尼西钠 Manual
Contents
1. RPLS RPLS RPLS RPLS2. BP20689 5mg kg 10mg kg 1Smg kg 39 5 15mg kg
3. RPLS 1
4. 28 4
5. VEGF 1 em 90 1 10 mg kg Ve 2 73L 3 28L IgG Vp
6. So j 0 5 Se 3 8 1 7 0 8 2 3
7. 1 gt 22 NCI CTC 3 5 gt 10 NCI CTC 1 5 gt 10 gt 1 10
8. 5 65 lt 65 65 3 4 lt 65 1 FE 65
9. CNS gt 1 2 28 28 5 NCI CTC 3 4 Avastin Bevacizumab Injection Bei Fa Zhu Dankang Zhusheye VEGF 100 mg 400 mg 4 ml 16 ml 25 m
10. 3 3 gt 1 2 Ne
11. 4 0 4 17 9 1 0 1 Wa 34 14 NCI CTC 3 4 4 0 2
12. OCRC py AVF2107g 5 4 6 AVF0780g S E 5 mg kg 6 8 Roswell Park AVF2192g 5 FU LV 5 FU LV 20 mg kg 2
13. PK a 2a IFL 5 FUILV WEDNIDWNDD EB AVF3135g SN38 NP18587
14. 13 26 4 2 50 mg kg 10 100 mg kg
15. 2009 1 5 7 77 86 SAEs SAE 625 SAE 12 3 77 625 29 19 25 86 SAE 2 SAE SAE
16. IFL 813 IFL 1 IFEL 5 mg kg 2 2 3 110 5 FU LV 3 IFL 3 IFL 2
17. mCRC m IFL IFL 5 mg kg Bolus
18. mgy kg 0 85 1 01 1 21 10mg kg 0 97 1 01 1 02 15mg kg 1 01 1 01 1 01 5mg kg 10mg kg PK 3mg kg 10mg kg AVF0737g PK 7 7 AVF0737g BP20689 PK mg kg ml day kg ml kg 3 65 41 4 AVF0737g 10 2 75 43 5 5 3 41 41 1 BP20689 10 3 16 41 0 28 2 C 8
19. 350 3 NO16966 mCRC EE CL CL FOLFOX 4 85 mg m IV 2h 1 FOLFOX 4 200 mg m IV 2h 1 2 5 Es Dz 400 mg m IV 1 2 600 mg m2 IV 22h 5 IV 5 mg kg IV 30 90 min FOLFOX 4 2 XELOX 130 mg m IV 2h 1 XELOX 1000 mg m 2 1 7 5 mg kg IV 30 90 XELOX min 3
20. 4 lt 3 Nr CHF CHF a CHF CHF TT NX
21. 4 ITT NO16966 FOLFOX 4 FOLFOX 4 P XELOX XELOX n 701 n 699 8 0 9 4 0 0023 97 5 CI 0 83 0 72 0 95 7 9 10 4 lt 0 0001 97 5 CI 0 63 0 52 0 75 8 5 11 0 lt 0 0001 97 5 CI 0 70 0 58 0 83 49 2 46 5 37 5 37 5 9 97 5 CI 0 89 0 76 1 03 2007 1 31 2006 1 31 ECOG E3200 II 21 NO16966 3 10 mg kg 5
22. IgG 6 IgG 6 FE
23. 28 60 60 10 4 40 20 3 15 1 1 0 9 3 5 AVF3708g 3 6
24. 5 II AVF2119g CHF E2100 BO17708 AVF3694g AVF3693g 3 3 CHF 3 5 0 9 CHF CHF CHF U 28 NYHA IILIV CHF
25. 26 100 mg kg 80 4 26 B24 26 FF 10 mg kg 50 mg kg
26. 1 2 4 AVF3708g 1 CNS 13 3 3 3 4 96 1 5 1 2 2 ID 83 50 NCI CTC 1 5 Hb Li ey E
27. 48 2C 8C 1 24 JS20050034 100mg 4ml S20100023 400mg 16ml S20100024 re 24 2C 30 C 0 9 29 5 Roche Pharma Schweiz Ltd Schoenmattstrasse 2 4153 Reinach Switzerland Genentech Inc DNA Way South San Francisco California 94080 U S A Hofftmann La Roche Ltd Wurmisweg 4303 Kaiseraugst Switzerland
28. E 0 2 1 gt 0 1 lt 1 Et ID Ne E 6 HM S5PBXPIN WM ZI 2 9 1
29. 2 AVF2107g AVF2107g 1 2 IFL IFL 411 402 15 6 20 3 95 CI 14 29 16 99 18 46 24 18 0 660 p 0 00004 6 2 10 6 0 54 p lt 0 0001 34 8 44 8 p lt 0 0036 5 mg kg 2 3 5 FU LV 110 18 3 AVF2192g 8 8 I 5 FU LV 105 5 FU LV 104 5 FU LV 5 mg kg 2
30. 2 IFL 5 3 6 8 Roswell Park NO16966 E3200 FOLFOX4 5 FU LV XELOX NO16966 7 5 mg kg 3 XELOX 5mg kg 2 5 5 5 FOLFOX 4 AVF2107g FOLFOX 4 E3200 10mg kg 2
31. RPLS RPLS CTIA MI 65
32. NSCLC Re NSCLC 9 3 5 2 3 EY FE Eb DA TH CNS Eb DA 91 1 ce Eb Eb UN CNS
33. 0 9 Qt 1 4 16 5 mg ml 4 5 E i AS j
34. 1 3 0 7 38 3 1 3 7 4 1 4 Nt lt lt 2 g 24 1 gt 2g 24
35. 1 NCI CTC 3 5 SOC 0 gt 10 RN i J 1 es
36. 3 4 gt 2 PT ELISAs 500
37. j TE
38. XELOX 20 FEFOLEFOX 4 E FOLFOX 4 XELOX i XELOX FOLFOX 4 4 CIRC 4
39. 5 FU LYV 5 mg kg 2 5 FU LY NO16966 7 5 mg kg 3 XELOX 5 mg kg 2 5 FU 5 FU FOLFOX 4 I XELOX FOLFOX 4 4 2x2 XELOX FOLFOX 4 XELOX FOLFOX 4 3
40. E 2 mg kg 0 5 2 mg kg 2 mg kg 10 mg kg 0 5 mg kg 5 Ne E 23 50 mg kg
41. 1100 021 28922888 021 50801167 8008208780 4008208780 30
42. 3 2 1 1 1 4 26 gt 0 8 F f 24
43. 2 4 2 84 3 8 3 79 FE vv CNS 1 J NCI CTC 3 5 0 4 5 0 NSCLC 5 1 h
44. FOLFOX 4 2 5 FOLFOX 4 829 FOLFOX 4 292 FOLFOX 4 293 244 FOLFOX 4 9 FP 5 5 E3200 E E3200 FOLFOX 4 FOLFOX 4 292 293 10 8 13 0 95 CI 10 12 11 86 12 09 14 03 0 751 p 0 0012 4 5 7 5 0 518 Cp lt 0 0001 8 6 22 2 p lt 0 0001
45. 4 Tn pA
46. 8 E 2 50 mg kg
47. BE L VEGF VEGF DNA j lt 0 35 ppm 20 214 149 000 VEGF Flt 1 KDR VEGF 2
48. 10 mg kg 2 FOLFOX 4 FOLFOX 4 BO20696 BO20696 hE 5 mg kg 2 22 ll Ey 6 kt 214 FU LY E PFS PFS ORR OS DoR 1 2 35 FU LV m IFL 5 FAS N
49. 2010 02 26 2010 04 10 2010 07 29 0 3 2 4
50. 0 5 1 4 FE 0 7 AVF21928g 11 11 100 5 8 6 104 3 2 15 6 2 8 17 3 A 3 5 7 8 4 9
51. PP N 171 N 211 3 3 3 3 1 2 3 3 1 98 6 97 2 3 5 61 4 68 8 13 70 18 6 14 141 9 9
52. 4 HM 3 4
53. 1 69L 2 35L Ve 20 IV VEGF IgG IgG IgG FcRn 3 0 188 0 220 L 17 18 20 2
54. NCI CTC 1 2 2 X
55. BO17705 a 2a 4 BO17704 4 BO17704 2 10mg kg 50mg 19 7 MAHA MAHA RPLS
56. 203 6 1 10 6 BO20696 m IFL m IFL m IFL 64 139 4 2 8 3 95 CI 3 7 4 9 7 4 8 9 p Log Rank lt 0 001 0 44 95 CI 0 31 0 63 13 4 18 7 95 CI 10 12 11 86 12 09 14 03 p Log Rank 0 014 0 62 95 CI 0 41 0 95 17 2 35 3 95 CI 8 4 27 7 27 5 43 5 p Pearson 0 013 m IFL 500 mg m 6 8 1 4 125 mg m 90 20 mg m2 1 2 5 6 1 lt 23 FAS ITT N 214
57. e 1 e 7 e I e e RPLS e e 4 e e 3 500 i NSCLC
58. g ml ua 20 USP pH 5 9 6 3 5 100mg 4ml 100mg 25mg ml 4ml 400mg 16ml 400mg 5mg ml 16ml 90 Ss 30 60 60
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